Drosophila Immunity: Analysis of PGRP-SB1 Expression, Enzymatic Activity and Function
نویسندگان
چکیده
منابع مشابه
Drosophila Immunity: Analysis of PGRP-SB1 Expression, Enzymatic Activity and Function
Peptidoglycan is an essential and specific component of the bacterial cell wall and therefore is an ideal recognition signature for the immune system. Peptidoglycan recognition proteins (PGRPs) are conserved from insects to mammals and able to bind PGN (non-catalytic PGRPs) and, in some cases, to efficiently degrade it (catalytic PGRPs). In Drosophila, several non-catalytic PGRPs function as se...
متن کاملEcdysone triggered PGRP-LC expression controls Drosophila innate immunity.
Throughout the animal kingdom, steroid hormones have been implicated in the defense against microbial infection, but how these systemic signals control immunity is unclear. Here, we show that the steroid hormone ecdysone controls the expression of the pattern recognition receptor PGRP-LC in Drosophila, thereby tightly regulating innate immune recognition and defense against bacterial infection....
متن کاملFunctional Analysis of PGRP-LA in Drosophila Immunity
PeptidoGlycan Recognition Proteins (PGRPs) are key regulators of the insect innate antibacterial response. Even if they have been intensively studied, some of them have yet unknown functions. Here, we present a functional analysis of PGRP-LA, an as yet uncharacterized Drosophila PGRP. The PGRP-LA gene is located in cluster with PGRP-LC and PGRP-LF, which encode a receptor and a negative regulat...
متن کاملPeptidoglycan recognition protein (PGRP)-LE and PGRP-LC act synergistically in Drosophila immunity.
In innate immunity, pattern recognition molecules recognize cell wall components of microorganisms and activate subsequent immune responses, such as the induction of antimicrobial peptides and melanization in Drosophila. The diaminopimelic acid (DAP)-type peptidoglycan potently activates imd-dependent induction of antibacterial peptides. Peptidoglycan recognition protein (PGRP) family members a...
متن کاملThe multiple functions of the PGRP family in Drosophila immunity
The innate immune system discriminates between infectious non-self and self using germ-lineencoded pattern recognition receptors (PRRs) that are highly conserved from insects to mammals. Peptidoglycan recognition protein (PGRP) is one of the hallmark pattern recognition receptors responsible for detecting unique bacteria-derived peptidoglycans. The PGRP family comprises several members (13 in D...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0017231